A Fast Algorithm for Using Semi-Parametric Random Effects Model for Analyzing Longitudinal Data
Abstract
Mixed effects models are frequently used for analyzing longitudinal data. Normality assumption of random effects distrbution is a routine assumption for these models, violation of which leads to model misspecifcation and misleading parameter estimates. We propose a semi-parametric approach using gradient function for random effect estimation. In this approach, we relax the normality assumption for random effects by estimating their distribution over a pre-specifed grid. Unknown parameters of the marginal model are estimated using maximum likelihood methods. Some simulation studies and analyzing of a real data set are performed for illustration of the proposed semi-parametric method.References
Ganjali, M., Baghfalaki, T., and Khazaei, M. (2013). A linear mixed model for analyzing longitudinal skew-normal responses with random dropout. Journal of the Korean Statistical Society, 42(2), 149–160.
Goldman, A. I., Carlin, B. P., Crane, L. R., Launer, C., Korvick, J. A., Deyton. L, and Abrams, D. I. (1996). Response of CD4+ and Clinical Consequences to Treatment Using ddI or ddC in Patients with Advanced HIV Infection. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 11, 161–169.
Ishwaran, H., and Takahara, G. (2002). Independent and identically distributed Monte Carlo algorithms for semiparametric linear mixed models. Journal of American Statistical Association, 97, 1154-1166.
Laird, N. (1978). Nonparametric maximum likelihood estimation of a mixing distribution. Journal of the American Statistical Association, 73, 805-811.
Laird,N.M., and Ware,J.H. (1982).Randomeffectsmodelsforlongitudinaldata. Biometrics,3 8, 963–974.
Lange, K. L., and J. S. Sinsheimer (1993). Normal/independent distributions and their applications in robust regression. Journal of the American Statistical Association , 2:175-198.
Lin, T., and Lee, J. (2008). Estimation and prediction in linear mixed models with skew-normal random effects for longitudinal data. Statistics in Medicine, 27, 1490–1507.
Lindsay, B. G. (1983). The geometry of mixture likelihoods: A general theory. The Annals of Statistics, 11, 86-94.
Pinheiro, J. C., Liu, C. H., and Wu, Y. N. (2001). Efficient algorithms for robust estimation in linear mixed-effects models using the multivariate t distribution. Journal of Computational and Graphical Statistics, 10, 249-276.
Rice, J. A., and Wu, C. O. (2001). Nonparametric mixed effects models for unequally sampled noisy curves. Biometrics, 57, 253-259.
Rosa, G. J. M., Padovani, C. R. and Gianola, D. (2003). Robust linear mixed models with normal/independent distributions and Bayesian MCMC implementation. Biometrical Journal,45, 573-590.
Shi, M., Weiss, R. E., Taylor, J. M. G. (1996). An analysis of paediatric CD4 counts for acquired immune deficiency syndrome using flexible random curves. Applied Statistics, 45,151-163.
Tsonaka, R., Verbeke, G., and Lesaffre, E. A. (2009). Semi-parametric shared parameter model to handle nonmonotone nonignorable missingness. Biometrics, 65, 81–87.
Verbeke, G., and Lesaffre, E. (1997). The effect of misspecifying the random effects distribution in linear mixed models for longitudinal data. Computational Statistics and Data Analysis, 23, 541–556.
Zhang, D., and Davidian, M. (2001). Linear mixed models with flexible distributions of random effects for longitudinal data. Biometrics, 57, 795-802.
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